PLGA microsphere/P(NIPAAm-co-AAm) hydrogel combination systems for drug delivery

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归属学者：

杨桔

归属院系：

刑事侦查学院

作者：

Yang, J.

摘要：

A combination drug delivery system was successfully prepared by dispelling drugloaded-poly (lactic-co-glycolic acid) (PLGA) microspheres into porous poly (N-isopropylamide- co-acrylamide) P(NIPAAm- co-AAm) hydrogel. Scanning electronic microscope (SEM) studies revealed that PLGA microspheres were encased into the interconnected porous structure of P(NIPAAm-co-AAm) hydrogel. In vitro release of Bovine serum albumin (BSA) from combination system exhibited a lower burst release followed by a slower sustained release as compared to BSA release from the PLGA microspheres and P(NIPAAm-co-AAm) hydrogels alone. These results demonstrated that the combination systems have the potential application in drug delivery.

语种：

英文

学科：

机械工程; 材料科学与工程

收录：

CPCI-S

提交日期：

2019-08-30

引用参考：

Yang, J.. PLGA microsphere/P(NIPAAm-co-AAm) hydrogel combination systems for drug delivery[A]. 2ND INTERNATIONAL WORKSHOP ON MATERIALS SCIENCE AND MECHANICAL ENGINEERING (IWMSME2018)[C]. ,2019:.

  • dc.title
  • PLGA microsphere/P(NIPAAm-co-AAm) hydrogel combination systems for drug delivery
  • dc.contributor.author
  • Yang, J.
  • dc.contributor.affiliation
  • Southwest Univ Polit Sci & Law, Chongqing Inst Higher Learning Ctr Forens Sci Eng, Chongqing 401120, Peoples R China;Southwest Univ Polit Sci & Law, Coll Criminal Invest, Chongqing 401120, Peoples R China;
  • dc.contributor.corresponding
  • Yang, J (reprint author), Southwest Univ Polit Sci & Law, Chongqing Inst Higher Learning Ctr Forens Sci Eng, Chongqing 401120, Peoples R China.; Yang, J (reprint author), Southwest Univ Polit Sci & Law, Coll Criminal Invest, Chongqing 401120, Peoples R China.
  • dc.contributor.conference
  • 2nd International Workshop on Materials Science and Mechanical Engineering (IWMSME)
  • dc.publisher
  • 2ND INTERNATIONAL WORKSHOP ON MATERIALS SCIENCE AND MECHANICAL ENGINEERING (IWMSME2018)
  • dc.identifier.year
  • 2019
  • dc.identifier.volume
  • 504
  • dc.date.issued
  • 2019
  • dc.language.iso
  • 英文
  • dc.description.abstract
  • A combination drug delivery system was successfully prepared by dispelling drugloaded-poly (lactic-co-glycolic acid) (PLGA) microspheres into porous poly (N-isopropylamide- co-acrylamide) P(NIPAAm- co-AAm) hydrogel. Scanning electronic microscope (SEM) studies revealed that PLGA microspheres were encased into the interconnected porous structure of P(NIPAAm-co-AAm) hydrogel. In vitro release of Bovine serum albumin (BSA) from combination system exhibited a lower burst release followed by a slower sustained release as compared to BSA release from the PLGA microspheres and P(NIPAAm-co-AAm) hydrogels alone. These results demonstrated that the combination systems have the potential application in drug delivery.
  • dc.description.sponsorship
  • Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJ1701001]; Fundamental Research Funds for the Central Universities [CDJXS10231119]; University-level research projects of Southwest University of Political Science and Law [2011-XZQN11]
  • dc.identifier.date
  • OCT 26-28, 2018
  • dc.identifier.addr
  • Qingdao, PEOPLES R CHINA
  • dc.identifier.issn
  • 1757-8981
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